|
Thursday, 24 September 2009 18:00 |
|
Abnormalities in the production and/or release of relaxing factors from the endothelium have been implicated in the development of hypertension in several animal models. Endothelium-dependent relaxation has been reported to be impaired in thoracic aorta in experimentally induced and genetically hypertensive rats. Present study has extented these observations to thoracic aorta of cadmium-hypertensive rats. The possible role of alterations in oxidant status was also studied. Hypertension was induced by the intraperitoneal administration of 1 mg/kg/day cadmium for 15 days. Mechanical responses produced by acetylcholine (ACh, 10— 9—10—4 M) and sodium nitroprusside (SNP, 10—10—10— 5 M) were studied on phenylephrine-precontracted thoracic aorta rings from cont... |
|
Thursday, 24 September 2009 18:00 |
|
Pan masala is commonly consumed in south-east Asian and other oriental countries as an alternate of tobacco chewing and smoking. Genotoxic potential of pan masala (pan masala plain and pan masala with tobacco known as gutkha) was evaluated employing chromosome aberration (CA) and micronucleus (MN) assay in vivo. Animals were exposed to three different doses (0.5%, 1.5% and 3%) of pan masala plain (PMP) and gutkha (PMT) through feed for a period of 6 months and micronucleus and chromosomal aberrations were studied in the bone marrow cells. Induction of mean micronuclei in polychromatic erythrocytes (MNPCE) and normochromatic erythrocyte (MNNCE) was higher in both types of pan masala treated groups with respect to control group. Both pan masala plain and gutkha treatment significantly induce... |
|
Tuesday, 25 August 2009 00:00 |
|
Nanotechnology Consumer Products Inventory now contains over 1,000 nanotechnology-enabled consumer products, reflecting the increasing use of tiny particles in everything from conventional products like non-stick cookware and lighter, stronger tennis racquets, to more unique items such as wearable sensors that monitor posture. |
|
Tuesday, 18 August 2009 00:00 |
|
The “Nano Metro” landscape is growing. An updated interactive map highlights companies, universities, government laboratories, and other organizations that are involved in nanotechnology research, development, and commercialization. |
|
Monday, 10 August 2009 18:00 |
|
Experimental studies in our laboratory have established the role of -aminolevulinic acid dehydratase (ALAD) and matrix -carboxyglutamic acid (MGP) gene polymorphisms in the etiology of lead toxicity. Polymorphisms in these genes influenced the levels of lead in subjects exposed to this metal. In extension to our studies, we aimed to investigate the possible role of these proteins in evolution by studying the phylogenetic relationship and divergence of ALAD and MGP genes using computational phylogenetic methods. The human ALAD and MGP protein sequences from various species were retrieved from Swiss-Prot database and were compared using Basic Local Alignment Search Tool. Multiple sequence alignment was carried out using ClustalW with defaults, and phylogenetic trees for both the genes were b... |
|
|
Monday, 10 August 2009 18:00 |
|
In conclusion, HDN has proven protective effects in BaP-induced testicular toxicity paradigm, and this protection resides, at least in part, on its antioxidant properties. (Source: Toxicology and Industrial Health current issue) |
|
Monday, 10 August 2009 18:00 |
|
The aim of this study was to investigate the effects of melatonin and vitamin C on expression of endothelial nitric oxide synthase (NOS) in heart tissue of chronic alcoholic rats. Twenty-four adult male Wistar rats weighing 200–250 g were used in this study. Rats were divided into four groups. The first group served as control (n = 6). The second group was treated with ethanol (%7.2) for 28 days (n = 6), which was administered in artificial isocaloric diets. The third group was given ethanol and supplemented with 40 mg/kg vitamin C [intraperitoneally (i.p.)] (n = 6). The fourth group was given ethanol and supplemented with 4 mg/kg melatonin (i.p.) (n = 6). At the end of the experiment, rats were sacrificed and heart tissues ... |
|
Monday, 10 August 2009 18:00 |
|
In conclusion, these results provide some evidence for a potential role of decreased antioxidant enzymes, MEL, and respiratory function test values in BA. (Source: Toxicology and Industrial Health current issue) |
|
Monday, 10 August 2009 18:00 |
|
The aim of this study is to evaluate whether occupational exposure to urban stressors could cause alterations in the follicle-stimulating hormone (FSH) levels in traffic policemen compared to a control group. After excluding the subjects with main confounding factors, traffic policemen and male controls were matched by age, working life, body mass index (BMI), drinking habit, cigarette smoking history, and daily consumption of Italian coffee, 166 traffic policemen and 166 controls were included into the study. FSH levels were significantly higher in traffic policemen compared to male controls (P < 0.05). The distribution of FSH values in traffic policemen and controls was significant (P < 0.05). Our results suggest that occupational exposure to low doses of chemic... |
|
Monday, 10 August 2009 18:00 |
|
Widespread use of mobile phones which are a major source of electromagnetic fields might affect living organisms. However, there has been no investigation concerning prenatal exposure to electromagnetic fields or their roles in the development of the pyramidal cells of the cornu ammonis in postnatal life. Two groups of pregnant rats, a control group and an experimental group, that were exposed to an electromagnetic field were used. For obtaining electromagnetic field offspring, the pregnant rats were exposed to 900 megahertz electromagnetic fields during the 1–19th gestation days. There were no actions performed on the control group during the same period. The offspring rats were spontaneously delivered—control group (n = 6) and electromagnetic field group (n =&n... |
|
